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Comparison of 3rd line immune checkpoint inhibitors to irinotecan-based chemotherapy in patient with refractory to paclitaxel plus ramucirumab : multi-center, observational study

Comparison of 3rd line immune checkpoint inhibitors to irinotecan-based chemotherapy in patient with refractory to paclitaxel plus ramucirumab : multi-center, observational study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0007732
Enrollment
500
Registered
2022-09-22
Start date
2022-06-01
Completion date
Unknown
Last updated
2022-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Soon Chun Hyang University Hospital Bucheon
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) 19 years of age or older 2) Histologically confirmed gastric adenocarcinoma 3) Patients who have been treated with weekly paclitaxel and ramucirumab combination therapy as palliative second-line systemic chemotherapy, or who have relapsed during or within 6 months of XELOX adjuvant chemotherapy after surgery and have been treated with weekly paclitaxel and ramucirumab 4) Patients who have received immune checkpoint chemotherapy (nivolumab or pembrolizumab) or irinotecan-based cytotoxic chemotherapy (irinotecan alone or FOLFIRI therapy) as third-line chemotherapy 5) Patients who received fluropyrimidine plus platinum+/-trastuzumab as primary anticancer treatment

Exclusion criteria

Exclusion criteria: 1) Patients who have metastatic cancer other than stomach cancer 2) Patients treated with irinotecan, nivolumab, or pembrolizumab as first-line or second-line palliative chemotherapy

Design outcomes

Primary

MeasureTime frame
Overall suvival

Secondary

MeasureTime frame
Progression-free survival, overall response rate, adverse events

Countries

Korea, Republic of

Contacts

Public ContactSung Hee Lim

Soon Chun Hyang University Hospital Bucheon

polluxis82@gmail.com+82-32-621-6950

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026