None listed
Conditions
Interventions
Others(Lifestyle modification) : The placebo group receives a PPI (esomeprazole 20 mg) for 4 weeks.
The experimental group receives a PPI for 4 weeks and also perform diaphragmatic breathing for 5 min
Sponsors
Yonsei University Health System, Gangnam Severance Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: -patients over 18 and under 76. -patients who recieved an endoscopy within 12 weeks from their first visit. -patients who report heartburn/regurgitatio symptoms at least one time/week for the past one months -patients with a GERD-Q score of over 8 -patients who understand the study protocol and can participate during the study period -patients who agree to participate in the study -child bearing patients who agree to contraceptives during the study period
Exclusion criteria
Exclusion criteria: -patients who cannot receive an endoscopy -patients with esophageal strictures, peptic stricutres, esophageal varices, long segment Barrett esophagus, active peptic ulcers, peptic ulcer bleeding, malignancies, eosinophilic esophagitis1 -primary esophageal motility disorders -patients who received surgery of the upper gastrointestinal tract other than simple closure of ulcer perforations or endoscopic reaction of being tumors. -patients with allergies to antacids, PPIs, P-CABs -patients receiving medication for psychological disorders -malignancies within 3 years -pregnancy or breastfeeding -past history of psychological disorders within the past 5 years -expected for hospital admission or surgery -determined by the investigator to be inappropriate to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of resolution of GERD symptoms | — |
Secondary
| Measure | Time frame |
|---|---|
| Absolute resolution of GERD symptoms | — |
Countries
Korea, Republic of
Contacts
Public ContactJoon Sung Kim
The Catholic University of Korea, Incheon St. Mary's Hospital
Outcome results
None listed