comparison between suction aspiration technique and combination technique of simultaneous use of aspiration catheter and retrieval stents in large artery occlusion required for intra-arterial recanalization therapy

Comparision of clinical and radiological outcomes between suction aspiration method and combination method of intra-arterial therapy (IAT) in large artery occlusion: prospective multicenter trials

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0007726

Enrollment

1132

Registered

2022-09-22

Start date

2022-10-01

Completion date

Unknown

Last updated

2022-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Medical Device : successful recanalization rate of suction aspiration that is defined as Pt will not be inferior to that of combination method that is defined as Pc in acute cerebral infarction of lar

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - acute cerebral infarction with initial NIHSS = 4 - patients with agreement for clinical trials - detection of large artery occlusion based on CT or MR angiography - definition of large artery occlusion: 1) anterior circulation ICA, M1, M2 segment A1, A2 segment 2)posterior circulation Vertebrobasilar occlusion including P1 segment - Last normal time = 24 hours - Flow/volume mismatch = 1/2 based on perfusion image

Exclusion criteria

Exclusion criteria: - Previous disabled patients before MT (Karnofsky performance Status Scale(KPS) = 80) - Patient or patient’s guardian refused to the clinical trial - Small vessel disease of TOAST classification - Other determined etiologies of TOAST classification - Patients with Initial NIHSS = 3 - Diffusion/perfusion matched lesion or flow/volume matched lesion

Design outcomes

Primary

Measure	Time frame
comparison of clinical outcome 3 months after IAT between between suction aspiration and combination techniques in M2 occlusions;comparison of clinical outcome 3 months after IAT between rescue treatment of primary stenting and sequential treatment in large artery atherosclerotic steno-occlusion;10. comparison of radiological outcome between more than 1/2 based on flow/volume of CT perfusion and calculated volume of mismatch based on flow/volume of CT perfusion;15. comparison of clinical outcome 3 months after IAT between hot-line prehospital tele-communication and conventional group;comparison of clinical outcome using modified Rankin Scale (mRS) 3 months after IAT between suction aspiration and combination techniques;comparison of clinical outcome using mRS 3 months after IAT between suction aspiration and combination techniques;comparison of clinical outcome using mRS 3 months after IAT between between combination technique using 6mm sized stents and the others techniques in M1 occlusion	—

Measure

Time frame

comparison of clinical outcome 3 months after IAT between between suction aspiration and combination techniques in M2 occlusions;comparison of clinical outcome 3 months after IAT between rescue treatment of primary stenting and sequential treatment in large artery atherosclerotic steno-occlusion;10. comparison of radiological outcome between more than 1/2 based on flow/volume of CT perfusion and calculated volume of mismatch based on flow/volume of CT perfusion;15. comparison of clinical outcome 3 months after IAT between hot-line prehospital tele-communication and conventional group;comparison of clinical outcome using modified Rankin Scale (mRS) 3 months after IAT between suction aspiration and combination techniques;comparison of clinical outcome using mRS 3 months after IAT between suction aspiration and combination techniques;comparison of clinical outcome using mRS 3 months after IAT between between combination technique using 6mm sized stents and the others techniques in M1 occlusion

—

Secondary

Measure	Time frame
procedural morbidity and mortality rate ;non-procedural morbidity and mortality rate such as myocardial infarction, pneumonia, or sepsis	—

Countries

Korea, Republic of

Contacts

Public ContactSung-Chul jJin

Inje University Haeundae Paik Hospital

kkw1023@hanmail.net+82-51-797-2090

Outcome results