None listed
Conditions
Interventions
Dietary Supplement :
? Name of main ingredient: (ACP_01) ? Appearance and formulation: White powder/sachets ? Content: 2,500 mg/sachets ? Storage method: Store at room temperature (1-30 ?) ? Usage an
Sponsors
Daehan Chemtech Co., Ltd
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Men and women over the age of 35 and under the age of 60 2) Those whose eye wrinkles are Grade 3 or higher on both the left and right sides in the visual evaluation 3) Those with a moisture retention of 49 AU or less in both cheeks measured by Corneometer® at visits 1 and 2 4) A person who has agreed to participate in this human application test before the start of the human application test and filled out the Informed Consent Form
Exclusion criteria
Exclusion criteria: Those who meet one or more of the following conditions are excluded from the human test subjects. 1) Those who are currently being treated for severe cardiovascular, immune, respiratory, gastrointestinal/liver and biliary system, kidney and urinary system, nervous system, musculoskeletal system, infectious disease or malignancy 2) People with mental disorders such as schizophrenia, depression, drug addiction, alcohol use/induced disorder, etc. 3) Those with skin diseases such as atopic dermatitis and psoriasis 4) Those with skin abnormalities such as spots, acne, erythema, and capillary dilatation at the test site 5) Smokers or those who have not quit smoking for less than 1 year 6) Those who have undergone facial treatment such as botox or fillers within 6 months based on visit 1, or who have undergone facial skin dermabrasion or other skin care within 1 month (30 days) 7) Those who have used steroid-containing skin external agents on the face or oral retinoids/steroids within 3 months from Visit 1 8) Those who have taken anti-obesity drugs (fat absorption inhibitors, appetite suppressants, etc.), psychiatric drugs such as depression and schizophrenia, contraceptives or hormones, or diuretics within 1 month of visit 1. 9) Medicines and health functional foods aimed at improving skin wrinkles and moisturizing effects within 2 weeks of visit 1 (health functional foods containing antioxidants, hyaluronic acid, collagen, evening primrose oil, vitamins A, C, E containing medicines and health functions food, etc.) 10) Those who have used functional cosmetics for wrinkle improvement (retinoids, AHA, etc.), highly moisturizing cosmetics, or skin care devices (LED mask, ion booster, etc.) within 2 weeks of visit 1 11) Those with AST (GOT) or ALT (GPT) of 120 IU/L or more or ?-GTP of 180 IU/L or more 12) Those whose Creatinine is 2.4 mg/dL or higher 13) Those with TSH of 0.1 µIU/mL or less or 10 µIU/mL or more 14) Patients with uncontrolled hypertension (systolic blood pressure greater than 160 mmHg or diastolic blood pressure greater than 100 mmHg, measurement standard after 10 minutes of rest for human subjects) 15) Patients with uncontrolled diabetes mellitus (fasting blood sugar 180 mg/dL or higher) 16) Those who are pregnant, lactating, or planning to become pregnant during this human application test period 17) Those who have participated in other interventional clinical trials (including human trials) within 1 month from Visit 1, or who plan to participate in other interventional clinical trials (including human trials) after the start of this human trial 18) Those who are sensitive to or allergic to the food ingredients for this human application test 19) Those who are judged inappropriate by the investigator for other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin wrinkles (visual evaluation, Mark-Vu, PRIMOSCR); Skin moisture;Transdermal moisture loss;Skin elasticity;Whitening;Eye Wrinkle Volume;Human body Evaluation of the degree of improvement of the tester of the applied test;Assessment of the degree of improvement of the subject of the test for human application;Cosmetic use survey;diet survey | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs (blood pressure, pulse);Blood and urine tests (safety assessment);Pregnancy test (only for women of childbearing potential);Physical measurement (height, weight) | — |
Countries
Korea, Republic of
Contacts
Public Contacthongbi Kim
Global Medical Research Center
Outcome results
None listed