Effects of mannitol versus hypertonic saline on intraoperative cardiac index in patients undergoing supratentorial brain tumor craniotomy

Effects of mannitol versus hypertonic saline on intraoperative cardiac index in patients undergoing supratentorial brain tumor craniotomy: A prospective double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0007634

Enrollment

104

Registered

2022-08-09

Start date

2022-06-27

Completion date

Unknown

Last updated

2022-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : - 20% Mannitol: 1 g/kg (5 ml/kg) is infused through the central venous catheter for 20 minutes. - 3% NaCl: 0.15 g/kg (5 ml/kg) is infused through the central venous catheter for 20 minutes. 2

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: adult patients over the age of 19 undergoing supratentorial brain tumor craniotomy

Exclusion criteria

Exclusion criteria: Patients who do not agree to participate in the study Patients who are contraindicated to use mannitol or hypertonic saline Patients with a history of craniotomy Patients who are unable to complete consent papers on their own due to loss of consciousness Patients undergoing emergency surgery

Design outcomes

Primary

Measure	Time frame
Cardiac index	—

Secondary

Measure	Time frame
Optic nerve sheath diameter;Supratentorial epidural pressure;Brain relaxation score;Invasive arterial blood pressure;Central venous pressure;Heart rate;Oxygen saturation;Pulse pressure variation;Cardiac output;Stroke volume;Stroke volume variation;Systemic Vascular Resistance Index;Hypotension Prediction index;Bispectral index;Episode of hypotension;Osmotherapy dose;Dose of crystalloids/colloids;Dose of inotropics;Expected blood loss;Amount of transfusion;Urine output;Amount of propofol/remifentanil;Glasgow Coma Scale ;Time to extubation;Length of intensive care unit stay;Length of hospital stay;Anesthesia time;Operation time;Complications;Hematocrit;Partial pressure of oxygen;Partial pressure of carbon dioxide;Serum sodium concentration;Serum potassium concentration;Serum chloride concentration;Serum glucose concentration;Serum lactic acid concentration;Serum calcium concentration;Blood urea nitrogen;Serum creatinine concentration;Serum osmolality	—

Measure

Time frame

Optic nerve sheath diameter;Supratentorial epidural pressure;Brain relaxation score;Invasive arterial blood pressure;Central venous pressure;Heart rate;Oxygen saturation;Pulse pressure variation;Cardiac output;Stroke volume;Stroke volume variation;Systemic Vascular Resistance Index;Hypotension Prediction index;Bispectral index;Episode of hypotension;Osmotherapy dose;Dose of crystalloids/colloids;Dose of inotropics;Expected blood loss;Amount of transfusion;Urine output;Amount of propofol/remifentanil;Glasgow Coma Scale ;Time to extubation;Length of intensive care unit stay;Length of hospital stay;Anesthesia time;Operation time;Complications;Hematocrit;Partial pressure of oxygen;Partial pressure of carbon dioxide;Serum sodium concentration;Serum potassium concentration;Serum chloride concentration;Serum glucose concentration;Serum lactic acid concentration;Serum calcium concentration;Blood urea nitrogen;Serum creatinine concentration;Serum osmolality

—

Countries

Korea, Republic of

Contacts

Public ContactKyung Won Shin

Seoul National University Hospital

skwskw1@naver.com+82-2-2072-3108

Outcome results