A comparison of IL-6, IL-10, TNF-alpha serum level change between in total laparoscopic hysterectomy and myomectomy patient under total intravenous anesthesia (TIVA) using propofol and remimazolam

A comparison of interleukin-6, interleukin-10, tumor necrosis factor-alpha serum level change between in total laparoscopic hysterectomy and myomectomy patient under total intravenous anesthesia (TIVA) using propofol and remimazolam

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0007611

Enrollment

Registered

2022-08-05

Start date

2021-10-15

Completion date

Unknown

Last updated

2022-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Byfavo 50mg : remimazolam basylate 50mg Fresofol MCT injection 2% 1000mg /50ml) : propofol 1000mg/50ml TIVA (target controlled infusion of propofol(2.5~4mcg/ml), remifentanyl(2ng/ml) / TCI

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: This study was conducted with patients aged 20 to 65 who underwent laparoscopic hysterectomy or laparoscopic myomectomy under general anesthesia with ASA score (American society of anesthesiology physical state score) I and II.

Exclusion criteria

Exclusion criteria: The following patients are excluded from the study. Immune system disorder and systemic disorder (systemic lupus erythematosus, rheumatoid arthritis, leukemia, etc.), patients with drug allergy, patients taking steroids such as oral contraceptives or taking them within 6 months, drug addiction or alcoholism , patients with neuropsychiatric disorders, pregnancy, patients with a body mass index (BMI) of 25 or higher

Design outcomes

Primary

Measure	Time frame
Interleukin-6 ( IL-6 );Interleukin-10 ( IL-10 );tumor necrosis factor -alpha (TNF - a)	—

Secondary

Measure	Time frame
hospitality stay ;Blood pressure, heart rate, saturation ;numeric rating sclae of operation site pain ; dose of opioid analgesics (fentanyl, oxycodone);postoperative nausea and vomiting	—

Countries

Korea, Republic of

Contacts

Public ContactJihyun An

Daegu Fatima Hospital

anji43@naver.com+82-53-940-7434

Outcome results