A randomized controlled trial comparing remimazolam and propofol for induction of anesthesia in patients receiving Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Antagonists

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0007488

Enrollment

Registered

2022-06-30

Start date

2021-09-09

Completion date

Unknown

Last updated

2022-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : In the propofol group, 20 mg of lidocaine is administered intravenously right before drug administration. For induction of anesthesia, propofol is administered at 2 mg per 1 kg of ideal body we

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients receiving general anesthesia for planned surgery at our hospital 19 years old or older - 65 years old or younger Patients diagnosed with hypertension and taking ACEi/ARB medications Patients with ASA physical status classification ? or lower

Exclusion criteria

Exclusion criteria: Emergency surgery and outpatient surgery A person who has planned in advance to be transferred to the intensive care unit after surgery BMI = 35 Patients with uncontrolled high blood pressure (e.g., patients with systolic blood pressure >160 mmHg despite taking antihypertensive medications) People with hypersensitivity to propofol and benzodiazepines Maternal surgery and nursing mother surgery People with Child-Turcotte-Pugh Class C hepatic dysfunction Acute narrow-angle glaucoma People who are unable to communicate and have cognitive impairment who cannot understand the consent form

Design outcomes

Primary

Measure	Time frame
Hypotension	—

Secondary

Measure	Time frame
Heart rate, oxygen saturation and BIS	—

Countries

Korea, Republic of

Contacts

Public ContactYeong-Gwan Jeon

Yonsei University, Wonju Severance Christian Hospital

ygjeon@yonsei.ac.kr+82-33-741-1530

Outcome results