None listed
Conditions
Interventions
Drug : 1. PLD (40 mg / m2
IV over three hours in one day) to be repeated till progression or unacceptable toxicity every four weeks (28
days) (Cohort 1)
2. Weekly paclitaxel (80mg/m2 IV over three hou
Sponsors
Yonsei University Health System, Severance Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adults 20 years old or older. 2. Subjects with histologically confirmed epithelial adenocarcinoma of ovarian, fallopian tube or peritoneal origin 3. Eligible histologic epithelial cell types: high grade serous adenocarcinoma, high grade endometrioid adenocarcinoma, undifferentiated carcinoma, clear cell adenocarcinoma, mixed epithelial carcinoma, , and low-grade adenocarcinoma, or adenocarcinoma not otherwise specified (N.O.S.). [only up to 5 patients with non-high grade serous carcinoma will be included] 4. Prior PARP inhibitor exposure (progressed through a prior PARP inhibitor) 5. CA-125 = 50 U/ml 6. Prior platinum-based chemotherapy. 7. Cohort 1 : 1-3 prior lines of therapies / Cohort 2 : Previous treatments of the 4th line or more 8. Not eligible for platinum re-treatment (prior allergic reaction or residual toxicity, patients who are not able to receive (in the physician’s opinion) or willing to receive platinum treatment and platinum resistant patients) 9. Received prior bevacizumab or not eligible for bevacizumab due to medical 10. Adequate bone marrow function: - a. Absolute neutrophil count (ANC) = 1,500/µL - b. Platelets = 100,000/µL - c. Hemoglobin = 8.0 g/dL (Note: Blood transfusion is permitted up to 48 hours before first dose of study treatment). 11. Adequate liver function: - a. Bilirubin < 1.5 times upper limit normal (ULN) - b. Lactate Dehydrogenase (LDH), SGOT/AST and SGPT/ALT < 2.5 times ULN 12. Adequate renal function: a. Creatinine = 1.5 times ULN 13. ECOG Performance Status of 0 or 1. 14. For women of childbearing potential, must be willing to avoid pregnancy by using a highly effective method of contraception from the first dose of study treatment to 60 days after last dose of study treatment. 15. Sign informed consent and authorization permitting release of personal health information.
Exclusion criteria
Exclusion criteria: 1. Participant has mucinous, germ cell, or borderline tumor of the ovary 2. Female subjects who are lactating and breastfeeding, or have a positive serum pregnancy test within 7 days prior to the first dose of study treatment 3. Any serious medical or psychiatric illness that could, in the investigator’s opinion, potentially interfere with the completion of treatment according to this protocol. 4. Active autoimmune disease, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), ulcerative colitis, Crohn's Disease, multiple sclerosis (MS), or ankylosing spondylitis requiring active disease modifying treatment. 5. Known allergy to murine proteins or hypersensitivity to any of the excipients of the oregovomab and PLD. 6. Chronically treated with immunosuppressive drugs such as cyclosporine, adrenocorticotropic hormone (ACTH), etc. 7. Chronic therapeutic corticosteroid use, defined as > 5 days of prednisone or equivalent, with the exception of inhalers or those on a pre-planned steroid taper. 8. Recognized acquired, hereditary, or congenital immunodeficiency disease, including cellular immunodeficiencies, hypogammaglobulinemia or dysgammaglobulinemia. 9. Clinically significant active infection(s) at the time of screening. 10. Any of the following conditions (on-study testing is not required): - a. Known HIV-infected subjects unless on effective anti-retroviral therapy with an undetectable viral load within 6 months, or - b. Known or suspected hepatitis B if active infection (patients with chronic hepatitis B infection must have an undetectable HBV viral load on suppressive therapy, if indicated; positive surface antibody alone is not an exclusion), or - c. Known or suspected hepatitis C infection which has not been treated and cured unless currently on treatment with an undetectable viral load). 11. Uncontrolled or life-threatening diseases compromising safety evaluation. 12. Participant has a known additional malignancy that is progressing or has required active treatment within the past 2 years Note: Participants with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ (e.g. breast carcinoma, cervical cancer in situ, endometrial carcinoma) that have undergone potentially curative therapy are not excluded. Note: Participants with synchronous primary endometrial cancer or a past history of primary endometrial cancer that met the following conditions are not excluded: Stage not greater than IA: no more than superficial myometrial invasion. 13. Contraindications to the use of pressor agents 14. History or evidence upon physical examination of CNS disease, seizures not controlled with standard medical therapy, or any brain metastases. 15. Any of the following cardiovascular conditions: - a. Acute myocardial infarction within 6 months before the first dose of study treatment. - b. Current history of New York Heart Association (NYHA) Class III or IV heart failure (see Appendix H). - c. Evidence of current uncontrolled cardiovascular conditions including cardiac arrhythmias, angina, pulmonary hypertension, or electrocardiographic clinically significant findings. 16. Unable to read or understand or unable to sign the necessary written consent before starting treatment 17. Inability to attend or comply with treatment of follow-up scheduling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective response rate | — |
Secondary
| Measure | Time frame |
|---|---|
| progression-free survival;Overall survival (OS);Time to first Subsequent Therapy;Time to Second Subsequent Therapy;Duration of response;second objective disease progression | — |
Countries
Korea, Republic of
Contacts
Public ContactEunyeong Yang
Yonsei University Health System, Severance Hospital
Outcome results
None listed