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The efficacy of Leucine-enriched essential amino acid supplementation in knee osteoarthritis patients

The efficacy of Leucine-enriched essential amino acid supplementation in knee osteoarthritis patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0007363
Enrollment
70
Registered
2022-06-08
Start date
2022-04-22
Completion date
Unknown
Last updated
2022-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Dietary Supplement : - Experimental group: Ingested protein supplement containing essential amino acids for 8 weeks. Dissolve 2 packets a day in 120-150 mL of water and drink. The two packets contain

Sponsors

Mokdong Himchan Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: This study is planned to be conducted with 70 patients aged between 50 and under 80 with osteoarthritis of the knee, who voluntarily agreed.

Exclusion criteria

Exclusion criteria: - Patients who underwent knee joint surgery within 6 months from the start date of the experiment - Patients with a history of infectious arthritis, rheumatoid arthritis, tumors, or fractures - Patients with hypersensitivity - Patients with a history of anaphylactic reactions - Patients or a family member with an autoimmune disease in progress or a history of autoimmune disease - Patients who are judged to be inappropriate for this study by the judgment of the person in charge of the study, such as those with mental illness

Design outcomes

Primary

MeasureTime frame
Limb muscle mass evaluation (DEXA, BMD) evaluation, blood test result evaluation (CBC, Albumin, Blood sugar, Insulin, Interleukin IL-6, Creatine kinase, AST, ALT, BUN, Creatinine, eGFR, 25(OH)D, Total protein , ALP)

Secondary

MeasureTime frame
Physical performance evaluation (grip strength evaluation, calf walking speed, sitting and standing 5 times, etc.), KSS, SF-36, WOMAC, VAS

Countries

Korea, Republic of

Contacts

Public ContactHye Sun Ahn

Mokdong Himchan Hospital

ahs0614@naver.com+82-2-3219-9229

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026