None listed
Conditions
Interventions
None listed
Sponsors
Koera University Guro Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patient with left ventricular ejection fraction of 40% or less on echocardiogram within 3 months. 2. Patient with sinus rhythm without atrial fibrillation. 3. Patient who have experienced worsening heart failure within 4 weeks or have been newly diagnosed with heart failure. 1) Symptoms above NYHA II 2) NT-proBNP 800 = pg/mL 4. Patient who can take a brain MRI without assistance.
Exclusion criteria
Exclusion criteria: 1. Patient who has been diagnosed with atrial fibrillation or is being treated. 2. Patient who had a stroke or cerebral hemorrhage within 3 months of participation in the study. 3. Patient who has a myocardial infarction or needs surgery or vascular intervention for coronary artery disease at the time of participation in the study. 4. Patient who are taking more than one anti-platelet drug at the time of participation in the study. (COX-1 inhibitor such as aspirin, triflusal, ADP receptor antagonists such as clopidogrel, ticlopidine, prasugrel, ticagrelor. PDE-3 inhibitor such as cilostazol, dipyridamole. serotonin receptor antagonists such as sarpogrelate.) 5. Patient who are taking anticoagulation drug or need anticoagulation (e.g. mechanical valves, moderate to severe mitral stenosis, pulmonary thromboembolism or deep vein thrombosis.) 6. Patient with terminal heart failure expected to die within 6 months 7. Patient who is a bed-ridden state or cannot take a brain MRI without help. 8. Patient who have already been diagnosed with dementia and are taking drugs such as donepezil, galantamine and rivastigmine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cortical thickness;the number of cortical microinfarcts;number of lacunes;white matter hyperintensity severity;the number of microbleeds | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination, MMSE;Seoul Verbal learning Test;Digit Span Test;Stroop-CR;Phonemic Controlled Oral Word Association Test;Trail Making Test-B, TMT-B;Digit Symbol Coding, DSC;Korea version of Boston Naming Test, K-BNT;Semantic Controlled Oral Word Association Test;Rey–Osterrieth Complex Figure Copy Test | — |
Countries
Korea, Republic of
Contacts
Public ContactSu Jin Park
Koera University Guro Hospital
Outcome results
None listed