None listed
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) Adults 55 years of age or older 2) Patients with or without depression who meet the diagnostic criteria for mild cognitive impairment (A patient with a score of 0.5-2 in CDR or 2-5 in GDS and mild cognitive impairment with memory complaint, normal activities of daily living, normal general cognitive function, abnormal memory for age, and not demented) 3) A person who can read and understand the subject's explanation and consent form, and is capable of language skills at a level that can respond to questionnaires 4) A person who voluntarily decides to participate in this clinical trial and agrees to the consent form for research subject participation and can participate in the entire clinical trial period
Exclusion criteria
Exclusion criteria: 1) Those diagnosed with bipolar or psychotic major depressive disorder 2) Those with a history of uniaxial psychiatric disorders including intellectual disability, schizophrenia, alcoholism, and bipolar disorder 3) Stroke, convulsive disease, Parkinson's disease, multiple sclerosis, cerebral palsy, Huntington's disease, encephalitis, meningitis, liver disease beyond cirrhosis, kidney disease to the extent that dialysis is required patient 4) Those with a history of convulsions 5) Those who have found other neurological abnormalities that may cause memory impairment on medical examination 6) When it is judged that there is a problem in attaching EEG and DC stimulation electrodes due to scalp deformity, inflammatory reaction, or other dermatological problems 7) Those who have had cancer within the past 3 years 8) Those who have undergone cerebrovascular surgery, such as brain surgery or carotid artery surgery 9) Those who have difficulty breathing when sitting still 10) Those who have abused drugs in the past 5 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| brain function: electroencephalography(EEG), functional near-infrared spectroscopy ;Cognitive function: short-term memory, working memory, attention, executive function;psychological symtpoms: depression and anxiety;physical and physiological function: gait speed, functional mobility, blood pressure, pulse, temperature | — |
Secondary
| Measure | Time frame |
|---|---|
| blood biomarker: BDNF, IL1,6, amyloid beta, tau protein | — |
Countries
Korea, Republic of
Contacts
Hallym University Medical Center- Chuncheon