None listed
Conditions
Interventions
Drug : 1. The interventions
The experimental group inhaled phytoncide oil in a single session for 30 minutes by soaking 1ml of phytoncide oil in a dental mask and then putting it on the subject. The u
quantitative electroencephalogram (qEEG) recorded at baseline and post-intervention to explore the effects of phytoncides on brain activity.
3. Study 2 (main study)
Forty-four patients with mild cogn
Sponsors
Hallym University Medical Center- Chuncheon
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Adults over 55 years of age. 2) Those who meet the diagnostic criteria for mild cognitive impairment or early Alzheimer's dementia. (CDR 0.5-2 or GDS 2-5, and memory complaint, normal activities of daily living, normal general cognitive function, abnormal memory for age and, not demented patients with mild cognitive impairment or Alzheimer's disease) 3) A patient who can read and understand the subject's explanation and consent form, and is capable of language skills at a level that can respond to questionnaires. 4) A patient who has voluntarily decided to participate in this clinical trial and who has consented in writing to the informed consent form and can participate in the entire clinical trial period.
Exclusion criteria
Exclusion criteria: (1) Persons diagnosed with bipolar or psychotic major depressive disorder. (2) Persons with a history of uniaxial psychiatric disorders including intellectual disability, schizophrenia, alcoholism, and bipolar disorder. (3) Stroke, convulsive disease, Parkinson's disease, multiple sclerosis, cerebral palsy, Huntington's disease, encephalitis, meningitis, liver disease beyond cirrhosis, kidney disease to the extent of requiring dialysis, etc. that may interfere with completion of this cognitive training program; patient with medical condition. (4) Those with a history of convulsions. (5) Those who have found other neurological abnormalities that may cause memory impairment during medical examination. (6) When it is judged that there is a problem in attaching EEG and DC stimulation electrodes due to scalp deformity, inflammatory reaction, or other dermatological problems. (7) Those who have had cancer in the past 3 years. (8) Those who have undergone cerebrovascular surgery, such as brain surgery or carotid artery surgery. (9) Persons who have abused drugs in the past 5 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurophysiological marker: qEEG (quantitative electroencephalography), fNIRS (functional near-infrared spectroscopy);Cognitive function: memory, attention and executive function | — |
Secondary
| Measure | Time frame |
|---|---|
| Psychological index (visual analog scale): depression, anxiety and stress | — |
Countries
Korea, Republic of
Contacts
Public ContactJiheon Kim
Hallym University Medical Center- Chuncheon
Outcome results
None listed