None listed
Conditions
Interventions
Dietary Supplement : The test group consumes mature silkworm pills and a nutritional drink, and the control group consumes a placebo pill and a placebo drink. The control nutritional drink (150kcal/20
Sponsors
Ajou University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with mild cognitive impairment who are 50 years of age or older as of the date of consent(For women who have lost fertility due to menopause or surgery, etc., those who have passed 2 years or more) 2. No significant impairment of daily life: K-IADL less than 0.4 3. It must not be dementia in the judgment of the clinician. 4. Can read and write letters. 5. Subject gave written consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1. If there is a mental illness such as major depression 2. Dementia 3. Other degenerative brain diseases such as Parkinson's disease 4. Malignant tumors within 5 years that have not been cured 5. Revascularization or stenting within 1 year 6. Severe or unstable symptomatic cardiovascular disease 7. Patients with other medical conditions that may interfere with completion of clinical trials if there is evidence of other severe or unstable physical disease 8. Severe visual impairment, severe hearing impairment, or communication impairment to the extent that interventions and effectiveness evaluations cannot be performed. 9. The illiterate 10. When it is judged that it is difficult for the researcher to cooperate fully in the research 11. If there is difficulty in safely participating in the research in the judgment of the researcher 12. Participating in other drug research or interventional research 13. If you are taking two or more prescription medications for cognitive decline 14. If more than 3 months have not elapsed since starting a new prescription for cognitive decline or adjusting the dose 15. Those who have a clear history of allergy to certain foods or drugs or who have been diagnosed 16. If you are taking other dietary supplements, if more than 3 months have not elapsed since starting or adjusting the dose
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| K-RBANS change amount | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in K-MMSE, CDR, K-IADL, nutrient intake, blood markers(neurofilament light chain, amyloid ß, total tau, phosphorylated-tau), retention rate, intake compliance | — |
Countries
Korea, Republic of
Contacts
Public ContactKyunghwa Sun
Ajou University Hospital
Outcome results
None listed