The clinical effect of pregabalin on neuropathic pain in central sensitized patients who are treated with duloxetine after total knee arthroplasty: Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0007301

Enrollment

Registered

2022-05-18

Start date

2022-05-02

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Screening for central sensitization and neuropathic pain will be performed two weeks in advance of surgery for patients scheduled to undergo total knee arthroplasty, and is performed through a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ? Patients for total knee arthroplasty over the age of 19. ? Patients who have the will or ability to follow the doctor's instructions, including rehabilitation treatment such as joint exercise. ? Patients understand this study and agree in writing by the patient's own or by the patient's representative to participate in the study. ? Patients with central sensitization and neuropathic pain.

Exclusion criteria

Exclusion criteria: ? Local infection, sepsis, or neurological abnormalities in the lower extremities of the surgical site. ? Patients with inflammatory arthritis or crystalline sedimentary arthritis. ? Patients who are hypersensitive to duloxetin or prevalin sanctions or show excessive complications. ? Patients who received treatment for anemia within a month of surgery. ? Patients with uncontrolled hypertension with relaxed blood pressure of 100mmHg or more ? Patients with abnormal liver function (aspartate aminotransferase or alanine aminotransferase >60 IU litre) ? Patients who can't do rehabilitation alone or need assistance.

Design outcomes

Primary

Measure	Time frame
Visual Pain Scale	—

Secondary

Measure	Time frame
Western Ontario and McMaster University Arthritis Index (WOMAC) Scale;Knee range of motion	—

Countries

Korea, Republic of

Contacts

Public ContactJae Jung Kim

The Catholic University of Korea, Seoul St. Mary's Hospital

jaejung343@hanmail.net+82-2-2258-6369

Outcome results