Analysis of the difference of adverse reactions between oral immunotherapy protocols in patients with food allergy

Analysis of the difference in the incidence rate of adverse reactions between oral immunotherapy protocols according to the dose increase method in patients with food allergy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0007260

Enrollment

100

Registered

2022-05-06

Start date

2021-02-25

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Others(amount of food intake) : Food immunotherapy is a treatment for food allergy, which is exposed sufferers to allergens (foods) little by little to induce desensitization and finally achieve immun

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ? If one or more of eggs, milk, and wheat were positive in the food oral provocation test conducted within 12 months from the time of obtaining consent ? If food specific IgE (Uni-CAP) is 0.35 or higher within 12 months from the time of consent ? Subject and/or guardian consent to participate in the study

Exclusion criteria

Exclusion criteria: * Patients who cannot stop taking drugs (systemic steroids, immunosuppressants, immunotherapeutics, biologics, etc.) that may affect the food oral provocation test and skin prick test for a period that may affect the test * Patients who need to continue taking drugs that may aggravate symptoms during anaphylaxis (beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARB) or calcium channel blockers) * Patients with severe cardiopulmonary disease requiring continuous treatment * Patients with systemic diseases requiring a specific diet * However, if anaphylaxis occurs after ingestion of eggs, milk, or wheat, it does not fall under the exclusion criteria.

Design outcomes

Primary

Measure	Time frame
tolerance;adverse effect of oral immunotherapy	—

Secondary

Measure	Time frame
Specific IgE and specific IgG4;covariant factors influencing tolerance;psychological state following oral immunotherapy	—

Countries

Korea, Republic of

Contacts

Public ContactYeonghee Kim

Samsung Medical Center

salutavrillee@naver.com+82-2-3410-0804

Outcome results