None listed
Conditions
Interventions
Behavioral, Dietary Supplement : In a 1:1:1 ratio, participants were randomly assigned to the treatment group A which is provided with SUPERBRAIN multimodal intervention with ready-made nutritional su
Sponsors
Ewha Womans University Seoul Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age: 65-85 years old 2. Mild cognitive impairment (criteria defined by Petersen, etc.) and probable Alzheimer's disease dementia as clinically diagnosed 3. Simple cognitive function test (K-MMSE) is 17-27. 4. Clinical Dementia Rating: 0.5-1 5. Clinical Dementia Rating Scale, sum of boxes: 0.5-5 6. Having a caregiver who can attend together to interview and the programs 7. Subject agrees to participate in the study with written consent
Exclusion criteria
Exclusion criteria: 1. Organic brain diseases and degenerative diseases that can be a major cause of cognitive declines such as brain tumor, stroke, normal pressure hydrocephalus, Parkinson’s disease, Lewy body dementia, vascular dementia, and autoimmune encephalitis 2. Infective or metabolic disease that may result in cognitive impairment such as neurosyphilis, AIDS dementia, vitamin B12 deficiency, folic acid deficiency, and hypothyroidism 3. Major psychiatric illness 4. Epilepsy with intractable seizure 5. Acute disease state (pneumonia, sepsis, shock, etc.) or acute infective disease 6. Probable encephalopathy due to chronic liver disease or chronic kidney disease 7. Chronic pulmonary disease or cardiovascular disease on treatment 8. Any medical conditions preventing cooperation with the interventions, as determined by a study doctor 9. Significant visual or auditory impairment that may prevent cooperation with the study 10. Illiteracy 11. Inability to participate in the study cooperatively until the end 12. Inability to safely participate in the exercise program 13. Simultaneous participation in any other intervention trial 14. Subject disagrees to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total score of RBANS | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in EEG, gut microbiome, MNA, and blood biomarkers are evaluated as the secondary outcomes. | — |
Countries
Korea, Republic of
Contacts
Public Contactjee hyang jeong
Ewha Womans University Seoul Hospital
Outcome results
None listed