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Effect of the administration timing of neuromuscular blocking agents on gastric insufflation during anesthetic induction

Effect of the administration timing of neuromuscular blocking agents on gastric insufflation during anesthetic induction: a double-blind randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0007175
Enrollment
180
Registered
2022-04-12
Start date
2022-04-25
Completion date
Unknown
Last updated
2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : After peroxygenation with FiO2 of 0.8 for 10 breaths, propofol 1-2mg/kg is administered and neuromuscular monitoring is started. In the pre group, the inhalational agent and rocuronium 0.6 mg/k

Sponsors

Asan Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: A. Patients who were scheduled for elective laparoscopic surgery and required tracheal intubation B. Patients who were scheduled for performing balanced anesthesia ( sevoflurane + reminfentanil) C. Patients aged 19 to 80 years D. Americal Society Anesthesiologists (ASA) class = 3

Exclusion criteria

Exclusion criteria: A. Patients requiring awake intubation according to American Society Anesthesiologists (ASA) Difficult Airway Algorithm. B. Patients requiring rapid sequence intubation due to the possibility of increased risk of aspiration of gastric contents ( pregnant patient, patients with ascites or intestinal obstruction, etc.) C. If gastric insufflation is already present or gastric antrum is not clear on ultrasound exam before anesthesia induction D. In case of a full stomach in the ultrasound image performed before induction of anesthesia even after fasting E. Patients allergic to or contraindicated in the study drug F. Patients with neuromuscular disorder or taking medications that affect neuromuscular block G. Patients with ESRD on dialysis

Design outcomes

Primary

MeasureTime frame
Measurement of gastric insufflation and gastric volume

Secondary

MeasureTime frame
Presence of adverse events (coughing, desaturation, laryngospasm, gagging, difficult ventilation, difficult intubation);Mask ventilation grade ( Waters grading scale );Mask ventilation time, tracheal intubation time;Blood pressure, heart rate, oxygen saturation;Difficulty in video tracheal intubation (fremantle grade);Presence and grade of PONV

Countries

Korea, Republic of

Contacts

Public ContactDoo-Hwan Kim

Asan Medical Center

knaaddict@gmail.com+82-2-3010-1417

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026