None listed
Conditions
Interventions
Dietary Supplement : 1) Test foods
- Main ingredient name: GF Bacillus antioxidant enzyme SOD (GF101)
- Content: 350mg/capsule
- Dose: 2 capsules per serving (morning and evening), 1 capsule per dose
Sponsors
Biomlogic
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Those who are 20 years old or older and 50 years old or younger 2) Those with a body mass index (BMI) greater than 18 kg/m2 and less than 30 kg/m2 3) Those who meet the following criteria (1) Female: Those who are expected to undergo IVF treatment (2) Males: Males who want to become pregnant and those who are currently undergoing artificial insemination or in vitro fertilization and who do not meet the 2010 WHO standards in semen analysis - Ejaculated volume: 1.0 mL or more Possible) A person who meets any of the following (less than 100% of the WHO 2010 standard) ? Sperm count: 0 (exceeding) ~ 15x106/mL ? Motility: 0 (exceeding) ~ 40 % ? Strict morphology: <4 % 4) A person who has agreed to participate in this human application test before the start of the human application test and filled out the Informed Consent Form
Exclusion criteria
Exclusion criteria: 1) Those with uncontrolled endocrine disease or medical disease 2) Those who smoked excessively within 3 months based on Visit 1 (=10 cigarettes/day) 3) Those who consumed excessive alcohol within 3 months of Visit 1 (=340 g/week, about 7 bottles/week of soju, 1 bottle/day) or alcoholics 4) Women with moderate gynecological diseases (if there is a change in the uterine lumen due to endometriosis, submucosal fibroids, and polyps, pelvicitis, uterine malformations, hydrops of the fallopian tubes) You can participate if it is not related to infertility.) 5) Men with Seminal duct obstructuion 6) Men who need TESE/TESA implementation 7) Those who are receiving other auxiliary treatment (oriental medicine treatment, etc.) for the purpose of infertility treatment 8) Those who are judged inappropriate by the investigator for other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxidative stress marker(Blood SOD) | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxidative stress marker (blood Catalase, follicle and semen SOD and Catalase);Retrieved oocyte No grade, Fertilized embryo No, Fertilization rate, Transferred embryo grade, Preimplantation genetic diagnosis(Female);Ejaculated volume, Sperm count/motility, Motile sperm count, Morphology, Sperm DNA fragmentation, Sperm total leukocyte count(Male);Lipid profile(Total Cholesterol, HDL-Cholesterol, LDL-Cholesterol, Triglyceride);Inflammation marker(TNF-a, IL-1ß, IL-6, hs-CRP);Pregnancy rate, Pregnancy/Method;NK cell activity | — |
Countries
Korea, Republic of
Contacts
Public Contactsara kim
Bundang CHA General Hospital
Outcome results
None listed