None listed
Conditions
Interventions
Drug : Naxen F (naproxen) 500mg BID - A pale yellow elliptical tablet as a NSAIDs family.
Pregabalin 75 mg BID – a half of reddish brown and white hard capsule containing white or light yellow powde
60*8=480, 2 days, so about 1000 mcg) and 0.9% 100 ml of normal saline and 0.3 mg (1 A) of ramosetron are mixed. The injection rate is 2ml/hr, 0.5ml is administered at the time of bolus injection, and
Sponsors
Catholic Kwandong University International St.Mary's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age : from 19 years to 65 years old 2. Trauma within 3 weeks
Exclusion criteria
Exclusion criteria: 1. Pilon fracture, open fracture, multiple fractures 2. Charcot's arthropathy 3. Creatinine > 1.2mg/dl, GFR < 60ml/min/1.73m2, chronic renal disease, peptic ulcer, diabetes mellitus over 5 years, coronary heart disease or myocardial infarction within 1 year 4. Spinal anesthesia, patient who declined to receive PCA 5. Patients who are taking NSAIDs, pregabalin already or who have side effects against those 6. Any surgical history on ipsilateral ankle or arthritic history on ipsilateral ankle 7. Systemic arthritis such as rheumatoid arthritis, gout arthritis 8. Any contraindication to the using drugs 9. Pregnant or breast feeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain, Functional recovery, and bone union | — |
Secondary
| Measure | Time frame |
|---|---|
| Use, amount, and the time to first use of narcotic pain killers, any side effects of NSAIDs, pregabalin | — |
Countries
Korea, Republic of
Contacts
Public ContactDong Woo Shim
Catholic Kwandong University International St.Mary's Hospital
Outcome results
None listed