Effect of intravenous palonosetron on hypotension induced by spinal anesthesia for cesarean section: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0006966

Enrollment

Registered

2022-01-27

Start date

2022-02-08

Completion date

Unknown

Last updated

2023-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Before spinal anesthesia, palonosetron 0.075mg in the intervention group and ondansetron 4mg in the control group is injected intravenously.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Single-pregnancy mother aged 18 to 65 undergoing elective cesarean section under spinal anesthesia

Exclusion criteria

Exclusion criteria: Under 18 years old, over 65 years old, weight 45 kg or less, 100 kg or more, ASA 3 or more, patients with brain or psychiatric disorders or taking related drugs, patients with severe cardiovascular, kidney, liver, or hematologic abnormalities, emergency cesarean section, gestational hypertension, pre-eclampsia, eclampsia, mothers with pregnancy-related complications such as placenta previa, multiple-pregnancy, malformation in the fetus or when a very low birth weight infant weighing less than 1500 g is expected, when a patient refuses spinal anesthesia

Design outcomes

Primary

Measure	Time frame
Total amount of phenylephrine used until the time of infant delivery	—

Secondary

Measure	Time frame
Presence of side effects of spinal anesthesia such as hypotension, bradycardia, and/or shivering;Outcome variables for cesarean section such as APGAR score and operation time ;Outcome variables for main effects and side effects of experimental drugs such as nausea and vomiting	—

Countries

Korea, Republic of

Contacts

Public ContactCHONGWHA BAEK

Chung-Ang Univerisity Hospital

nbjhwa@naver.com+82-2-6299-2579

Outcome results