None listed
Conditions
Interventions
Drug : For the induction and maintenance of general anesthesia, remimazolam is used in the experimental group. Remimazolam (1mg/ml) infusion starts from 6 mg/kg/h intravenously and it can be increased
Sponsors
Samsung Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patient diagnosed with non-functioning pituitary tumor and scheduled for elective mass removal neurosurgery by transsphenoidal approach under general anesthesia. Age from 19 years to 69 years old.
Exclusion criteria
Exclusion criteria: patient with unstable vital sign, patient with neurologic deficiency, American Society of Anesthesia physical status equal or over III, Pregnant or breast feeding patient, patient with drug allergy, patient who has difficulty with communicating in Korean, Patient who disagree to participate Drop out: Difficulty in INM monitoring after induction, INM decreases more than 50%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| amplitude of motor evoked potential | — |
Secondary
| Measure | Time frame |
|---|---|
| coefficient of variation of motor evoked potential;systolic/diastolic/mean blood pressure, heart rate, cardiac output, cardiac index, pulse pressure variation, stroke volume variation;dosage and target concentration of remifentanil ;frequency of hypotension and bradycardia, dosage of ephedrine, phenylephrine and atropine, Use of continuous vasopressor | — |
Countries
Korea, Republic of
Contacts
Public Contacteun kyung lee
Samsung Medical Center
Outcome results
None listed