None listed
Conditions
Interventions
None listed
Sponsors
Yonsei University Health System, Severance Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Those who are 3 years of age or older at the time of selection and meet the conditions of ? or ? ? Refractive error> -6.0D or axial length> or = 26.5mm and myopic CNV was diagnosed. ? Diagnosis Criteria for Myopic CNV: When one of subretinal hemorrhage, hyperreflective lesion, intraretinal fluid, subretinal fluid, or RPE detachement is found on OCT (Ocular Optical Tomography). ? Refractive error> -9.0D or axial length> 28mm, and there is a family history of pathologic myopia. • Pathologic myopia criteria (one of the following) ? Refractive error> -9.0D or axial length> 28mm ? Have a history of Myopic maculopathy or posterior staphyloma
Exclusion criteria
Exclusion criteria: ? If the selection criteria are satisfied, but have a history of other retinal diseases such as diabetic retinopathy, uveitis, retinopathy of prematurity, and senile macular degeneration. ? If the selection criteria are satisfied, but there is a history of being diagnosed with other systemic diseases that may cause high myopia (Stickler syndrome, Marshall syndrome, Wagner syndrome, Ehlers Danlos syndrome, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mutation variant detected after whole exome sequencing | — |
Secondary
| Measure | Time frame |
|---|---|
| Mutation variant commonly found in subjects | — |
Countries
Korea, Republic of
Contacts
Public ContactYuri Seo
Yonsei University Health System, Severance Hospital
Outcome results
None listed