Comparison of hypotensive effect between remimazolam and propofol in anesthesia of elderly

Comparison of hypotensive effect induced by remimazolam and propofol during total intravenous anesthesia in the elderly - a randomized control trial.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0006719

Enrollment

132

Registered

2021-11-08

Start date

2021-11-08

Completion date

Unknown

Last updated

2023-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Both group undergoes total intravenous anesthesia. Intervention group uses remimazolam for hypnotic drug, and control group uses propofol. For intraoperative analgesia, remifentanil is administ

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - patients undergoing elective surgery with general anesthesia - laparoscopic cholecystectomy or transurethral bladder resection

Exclusion criteria

Exclusion criteria: - ASA PS classification > III - ambulatory surgery - unable to measure blood pressure at the upper arm non-invasively, or at radial artery invasively - chronic alcoholics - BMI = 30 - Hypersensitivity to remimazolam, propofol, remifentanil, ephedrine, rocuronium, sugammadex - Child-Turcotte-Pugh Class C - acute narrow angle glaucoma - mild cognitive disorder or more severe cognitive disorder - can not understand the informed consent form or lacks decision-making capacity

Design outcomes

Primary

Measure	Time frame
Incidence of hypotension	—

Secondary

Measure	Time frame
bradycardia and tachycardia;Delirium;unexpected admission to the ICU;mortality	—

Countries

Korea, Republic of

Contacts

Public ContactSeung Woo Song

Yonsei University Wonju College of Medicine

googlfong@gmail.com+82-33-741-1536

Outcome results