Appropriate treatment field margin and the reduction effect of the variation of liver position by taking the simethicone for radiation therapy of liver cancer

Appropriate treatment field margin and the reduction effect of the variation of liver position by taking the simethicone for image-guided and respiratory-gated radiation therapy of liver cancer

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0006550

Enrollment

Registered

2021-09-07

Start date

2021-10-04

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : The study design of the Experimental and the control group is identical except for the difference in the absence of simethicone. In the case of the simethicone group, from 3 days before the si

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with liver cancer who are subject to image-guided and respiratory-gated radiation therapy Performance status : ECOG 0~1 patient Liver function test : Child-pugh class A or some B patient Patients who agreed to participate in the study

Exclusion criteria

Exclusion criteria: Liver function test : Child-pugh class C patient Pregnant women, seniors over 80 years old, under 20 years old Patients who have difficulty understanding or following the medical staff`s instructions for image-guided and respiratory-gated radiation therapy

Design outcomes

Primary

Measure	Time frame
Evaluation of liver and kidney dose in radiation therapy plan;Measurement of relative positional variation in orthogonal OBI kV images (AP and lateral views) taken at 50% and 0% of the respiratory cycle of each treatment;Stomach volume setting and volume measurement in CBCT performed before each treatment;Measurement of hepatic and kidney position variation in CBCT performed before each treatment;Comparison of stomach volume and liver location variation according to whether of not simethicone was taken	—

Measure

Time frame

Evaluation of liver and kidney dose in radiation therapy plan;Measurement of relative positional variation in orthogonal OBI kV images (AP and lateral views) taken at 50% and 0% of the respiratory cycle of each treatment;Stomach volume setting and volume measurement in CBCT performed before each treatment;Measurement of hepatic and kidney position variation in CBCT performed before each treatment;Comparison of stomach volume and liver location variation according to whether of not simethicone was taken

—

Secondary

Measure	Time frame
Data on RT planning and treatment are collected through review of the Eclipse treatment planning system	—

Countries

Korea, Republic of

Contacts

Public ContactByungdo Park

Samsung Changwon Medical Center

byungdo.park@gmail.com+82-55-233-5668

Outcome results