The effect of 5-hydroxytryptamine-3 receptor antagonists on opioid-induced hypotension or bradycardia at anesthesia induction

The effect of 5-hydroxytryptamine-3 receptor antagonists on opioid-induced hypotension or bradycardia at anesthesia induction: double blinded randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0006543

Enrollment

200

Registered

2021-09-03

Start date

2021-10-01

Completion date

Unknown

Last updated

2023-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : In the intervention group, 0.3 mg/2 ml of Nasea (ramosetron 0.3 mg/2 ml) mixed with normal saline solution (Total 5mL) is administered intravenously at the anesthesia induction. In the control

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: ASA class I adult patient who undergoing laparoscopic gynecological surgery

Exclusion criteria

Exclusion criteria: 1. Emergency surgery, 2. Reoperation, 3. Calculation or soy oil allergy, 4. QT extension confirmed in preoperative ECG, 5. history of drug abuse, 6. In case of taking other drugs, 7. In case of co-operation with other surgery, 8. Short surgery within 1 hour.

Design outcomes

Primary

Measure	Time frame
Blood pressure	—

Secondary

Measure	Time frame
Postoperative nausea and vomiting	—

Countries

Korea, Republic of

Contacts

Public ContactSeung Wan Hong

Konkuk University Medical Center

20150077@kuh.ac.kr+82-2-2030-5448

Outcome results