The relationship between intraoperative dexmedetomidine, HMGB1 protein levels, and cognitive dysfunction

The relationship between HMGB1 protein levels before and after surgery and cognitive dysfunction in elderly patients in intraoperative dexmedetomidine infusion

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0006497

Enrollment

128

Registered

2021-08-24

Start date

2021-08-09

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Intraoperative Dexmedetomidine administration: Dexmedetomidine will be infused in rate of 0.05 cc/hr ~ 0.125 cc/hr (4mcg/cc, 0.2 ~ 0.5 mcg/kg/hr), from anesthesia induction to the end of surge

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing a non-cardiac surgery under general anesthesia who are aged over 64

Exclusion criteria

Exclusion criteria: Emergency operation, organ transplantation surgery, cardiac surgery Liver failure, renal failure. American Society of Anesthesiologists (ASA) physical classification 4 or 5 Underlying dementia, Parkinson's disease Unable to communicate or unclear mentality Refuse to write informed consent

Design outcomes

Primary

Measure	Time frame
HMGB1 blood level;Mini cog test result	—

Secondary

Measure	Time frame
Incidence of POCD	—

Countries

Korea, Republic of

Contacts

Public ContactSeunghee Yoo

Ewha Womans University Medical Center

yoosh0710@naver.com+82-2-2650-5285

Outcome results