None listed
Conditions
Interventions
None listed
Sponsors
Seoul National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? 19 years old or older and less than 80 years old ? Patients under follow-up at the Department of Endocrinology and Metabolism or Neurosurgery at Seoul National University Hospital who have had or are scheduled to undergo pituitary surgery ? Subjects who consent to donation of human material
Exclusion criteria
Exclusion criteria: ? Renal-urinary structural disease ? Uncontrolled diabetes mellitus (HbA1C >8.5% within the last 3 months) ? Taking medications that affect the amount of urine (diuretics, SGLT-2 inhibitors, lithium, etc.) ? Patients with nephrogenic diabetes insipidus ? Patients with suspected primary polydipsia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differentiation and predictive ability of copeptin concentration and change patterns measured before and after pituitary surgery for transient diabetes insipidus, permanent diabetes insipidus, and triphasic diabetes insipidus | — |
Secondary
| Measure | Time frame |
|---|---|
| Predictive ability of copeptin concentration measured after pituitary surgery for diabetes insipidus ;The ability to differentiate between excessive fluid supply and diabetes insipidus of copeptin concentration in the occurrence of hypotonic polyuria after pituitary surgery;Differentiation between ACTH/steroid deficiency and diabetes insipidus in postoperative polyuria in copeptin concentration | — |
Countries
Korea, Republic of
Contacts
Public ContactHan Na Jang
Seoul National University Hospital
Outcome results
None listed