None listed
Conditions
Interventions
Behavioral, Dietary Supplement : In order to prevent weight loss and increase skeletal muscle mass, for the intervention group, exercise and nutritional interventions with optimal life-log will be giv
Sponsors
National Research Foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Those who have been diagnosed with esophageal cancer and are over the age of 18 who are scheduled to undergo curative esophageal resection and reconstruction, and are under 80 years of age – Able to walk independently and live daily life - ECOG PS 0-1 – Those who can use a smartphone – Those who signed on the written informed consent to this study
Exclusion criteria
Exclusion criteria: - Those who have limited cognitive and communication skills or are currently receiving psychiatric treatment – Those who have had esophageal cancer treatment (surgery) within the last 1 year (excluding local treatments such as endoscopic resection) – Those who have previously had esophageal resection and reconstructive surgery – Those who are overseas residents or foreigners, and cannot be continuously followed – Those who are with limited physical ability to perform this intervention program: 1) Cardiac failure (New York Heart Association functional classes III and IV)) due to cardiovascular disease or cerebrovascular disease (cerebral hemorrhage, cerebral infarction, transient ischemic attack, stroke, cerebrovascular accident) If you are concerned about the worsening of the disease. 2) Patients unable to walk due to joint problems or paralysis 3) Patients with kidney dysfunction(estimated GFR<60mL/min/1.73m^2) 4) Patients who failed to proceeding to suffiecient oral intake postoperatively 5) Patients who did not meet the oral intake initiation within 14 days after surgery *Indication for drop-out: Inhospitalization more than 30-day after surgery since postoperative complication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of severe weight loss (= 10% comparing to pre-surgery weight) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Body weight (kg), body fat percentage (%), skeletal muscle mass index (SMI, kg/m2) measured by Bioelectrical impedance analysis (BIA), abdominal SMI(kg/m2) at lumbar 3 level and abdominal body fat percentage (%) measured by CT ;2) Quality of life and symptoms: EORTC QLQ-C30 & OES18, GSRS, depression (PHQ9) , Distress(NCCN distress thermometer and problem list); 3) Nutritional indicators (Lab): PNI, NRI (e.g. albumin, total protein, Hb, WBC, ANC, ALC, platelet, NLR, PLR); 4) Nutritional evaluation score: NRS-2002, MNA-SF, dietary habit (intake questionnaire, nutrition counseling), amount of oral intake(kcal, protein); 5) Physical function: grip (kg), 6MWT (m), CS (rep), physical activity level (step, MVPA during last 7-day);6) Complications within 2 months after surgery | — |
Countries
Korea, Republic of
Contacts
Public ContactYoung Mog Shim
Samsung Medical Center
Outcome results
None listed