Effect of subcutaneous nitroglycerin injection on success rate of arterial line placement in critically ill patients with continuous intravenous infusion of vasopressors

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0006369

Enrollment

136

Registered

2021-07-22

Start date

2021-07-15

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Nitroglycerin group : nitroglycerin 500 ? 0.5 ? + 2% lidocaine 0.5 ? total 1 ?, 1 time subcutaneous injection Control group: 0.9% normal saline 0.5 ? + 2% lidocaine 0.5 ? 1 ?, 1 time subcutane

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Among the patients in the surgical intensive care unit who are receiving continuous intravenous infusion of norepinephrine, adult patients (19 years of age or older) who require a arterial catheterization – When a new arterial catheterization is needed (ex. malfunction) – If there is no severe hemodynamic instability among patients who newly require arterial catheterization

Exclusion criteria

Exclusion criteria: ? Hypersensitivity or contraindication to nitroglycerin (glaucoma, increased intracranial pressure, intracranial hemorrhage, sildenafil or vardenafil) ? Hypersensitivity or contraindications to lidocaine ? History of puncture of the radial artery who are planning to attempt arterial catheterization within the last 24 hours ? Wounds, infections, or hematomas at the site where the arterial line is to be placed ? Peripheral vascular disease ? When it is impossible to collect research data on vascular placement due to hemodynamic instability (When norepinephrine requirement is 0.2 µg/kg/min or more) ? If the patient or surrogates refuses to proceed with the research

Design outcomes

Primary

Measure	Time frame
Success rate of first attempt of radial artery catheterization	—

Secondary

Measure	Time frame
the diameter of radial artery;the depth of radial artery from skin;Duration between initiation of procedure to success of first attempt of arterial catheterization;Duration between initiation of procedure to success of second attempt of arterial catheterization;Success rate of second attempt of radial artery catheterization;Change in the diameter of radial artery (vasodilation) with nitroglycerin or normal saline subcutaneous injection according to continuous intravenous infusion dose of norepinephrine (µg/kg/min);the proportion of hematoma development after arterial catheterization;the proportion of vasospasm development after arterial catheterization;the proportion of distal ischemia development after arterial catheterization;the proportion of hypotension development after arterial catheterization	—

Measure

Time frame

the diameter of radial artery;the depth of radial artery from skin;Duration between initiation of procedure to success of first attempt of arterial catheterization;Duration between initiation of procedure to success of second attempt of arterial catheterization;Success rate of second attempt of radial artery catheterization;Change in the diameter of radial artery (vasodilation) with nitroglycerin or normal saline subcutaneous injection according to continuous intravenous infusion dose of norepinephrine (µg/kg/min);the proportion of hematoma development after arterial catheterization;the proportion of vasospasm development after arterial catheterization;the proportion of distal ischemia development after arterial catheterization;the proportion of hypotension development after arterial catheterization

—

Countries

Korea, Republic of

Contacts

Public ContactHyunjae Im

Seoul National University Hospital

neptunelight88@gmail.com+82-2-2072-1683

Outcome results