Analgesic Efficacy of Nefopam on Acute and Chronic Pain After Video-Assisted Thoracoscopic surgery in lung cancer patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0006246

Enrollment

100

Registered

2021-06-11

Start date

2021-03-25

Completion date

Unknown

Last updated

2022-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : The nefopam group is administered 20mg of nefopam mixed with 100ml of normal saline intravenously for 15 minutes at immediately after anesthesia induction and 15 minutes before the end of surge

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: A. between 20 years old and 70 years old age B. American Society of Anesthesiologists physical status classification I~III C. video assisted thoracoscopic surgery for more than lung lobectomy D. Patients who can fill out a consent form or can get consent from a legal representative

Exclusion criteria

Exclusion criteria: A. under 19 years old age B. Pregnant or lactating women C. history of hypersenstivity allergic reaction to pain control medication (nefoparm or nefopam component hypersensitivity) D. kidney dysfunction or liver dysfunction E. history of epilepsy or convulsion F. history of myocardial infarction G. A patients who is administered MAO inhibitor H. A patients has urinary retension risk associated with ureteral or prostate disorders I. history of closed-angle glaucoma

Design outcomes

Primary

Measure	Time frame
cumulative dose of opioid use for postoperative 6 hours	—

Secondary

Measure	Time frame
cumulative dose of opioid use for postoperative 12, 24, 72 hours;surgical site pain score at postoperative 6, 12, 24, 72 hours;time to the first dose of rescue medication at general ward or ICU;surgical site pain score in the surgical wound postoperative 2 weeks;the incidence of chronic postoperative pain after 3 months of surgery;the incidence of adverse reaction of opioid use for postoperative 6 hours, for postoperative 12, 24, 72 hours;change of AST, ALT at postoperative day 1 and 3;incidence of intravenous patient-controlled analgesia bolus use at postoperative 12, 24 hours	—

Measure

Time frame

cumulative dose of opioid use for postoperative 12, 24, 72 hours;surgical site pain score at postoperative 6, 12, 24, 72 hours;time to the first dose of rescue medication at general ward or ICU;surgical site pain score in the surgical wound postoperative 2 weeks;the incidence of chronic postoperative pain after 3 months of surgery;the incidence of adverse reaction of opioid use for postoperative 6 hours, for postoperative 12, 24, 72 hours;change of AST, ALT at postoperative day 1 and 3;incidence of intravenous patient-controlled analgesia bolus use at postoperative 12, 24 hours

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Countries

Korea, Republic of

Contacts

Public ContactHyean YEO

Samsung Medical Center

hyean.yeo@samsung.com+82-2-3410-1994

Outcome results