None listed
Conditions
Interventions
None listed
Sponsors
Gachon University Gil Medical Center
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: -Women aged 19 years or older and under 45 years old -Those who fall under one of the following three 1) Patients with PCOS or obesity with amenorrhea or oligomenorrhea, who are expected to undergo obesity metabolic surgery 2) Patients with PCOS or obesity with amenorrhea or oligomenrrhea menstruation and undergoing life therapy treatment or observation 3) Normal control group (female reproductive function is normal and body mass index 18.5 to 24.9) -Or those who collect eggs for infertility
Exclusion criteria
Exclusion criteria: -Women under the age of 19 and over 45 -Those who are administering hormones that affect female reproductive function other than for the purpose of collecting oocytes or have been administered within the last 6 months -Diabetic patients taking antidiabetic drugs or insulin injection treatment -Those who are administering oral contraceptives or have been given oral contraceptives within the last 6 months -Those taking antihypertensive drugs -Those who are administering anti-obesity injections or oral drugs for the treatment of obesity, or have administered them within the last 3 months -Those who do not perform a pregnancy test or are unsure whether they are pregnant -If the average alcohol consumption per day for the past 2 years exceeded 20g (approximately 2 glasses of soju) and lasted for 3 months or more -Liver disease of other causes other than non-alcoholic fatty liver disease -History of taking drugs that cause secondary fatty liver within the last 1 year (corticosteroids, tamoxifen, amiodarone, methotrexate, etc.) -Patients with suspected female reproductive dysfunction due to causes other than obesity or PCOS -Those who are judged to be inappropriate to participate in this study due to other systemic diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of pathways most closely related to insulin resistance among the mechanisms related to female reproductive dysfunction (e.g., specific metabolites, hormones, or hepatokine, specific genetic mutations, pathways that can explain molecular biological mechanisms in follicular cells) | — |
Secondary
| Measure | Time frame |
|---|---|
| body weight, body fat, and liver fat content(MRI-measured) | — |
Countries
Korea, Republic of
Contacts
Public ContactDAE HO LEE
Gachon University Gil Medical Center
Outcome results
None listed