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Comparison of Postoperative Pulmonary Complications after Living-donor Liver Transplantation between Individualized Driving Pressure Guided Ventilation and Lung Protective Ventilation with Fixed Positive End-expiratory Pressure : a randomized controlled trial

Comparison of Postoperative Pulmonary Complications after Living-donor Liver Transplantation between Individualized Driving Pressure Guided Ventilation and Lung Protective Ventilation with Fixed Positive End-expiratory Pressure : a randomized controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0006040
Enrollment
200
Registered
2021-03-30
Start date
2021-04-12
Completion date
Unknown
Last updated
2021-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : 1. After the endotracheal intubation, attending clincian should adjust ventilatory parameter according to the guideline for liver transplantation of Samsung Medical Center as foll
After the plateu pressure reach the pressure of 30cmH2O, it is applied for ten breaths. During the recruitement maneuver, ventilation is set for a tidal volume (Vt) of 8 ml*kg PBW, respiratory rate (R

Sponsors

Samsung Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: adult recipient who undergo living donor liver transplantation at Samsung Medical Center

Exclusion criteria

Exclusion criteria: (1) pediatric patient under 19 (2) patient who doesn't agree the consent form of the study (3) patient with contraindication of positive end-expiratory pressure : increased intracranial pressure, broncho-pleural fistula, hypovolemic shock, modera to severe right ventricular dysfunction (4) patient with Gr3 or 4 encephalopathy (5) patient with preoperative pulmonary complication or history of lung surgery.

Design outcomes

Primary

MeasureTime frame
the incidence of postoperative pulmonary complication according to Melbourne group scale

Secondary

MeasureTime frame
Duration of mechanical ventilation after the surgery;length of ICU stay;length of hopital stay;30-day mortality after the surgery

Countries

Korea, Republic of

Contacts

Public ContactJeayoun Kim

Samsung Medical Center

kimjy0705@naver.com+82-2-3410-6580

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026