Ranitidine bismuth citrate pretreatment in H. pylori eradication

Influence of pretreatment with ranitidine bismuth citrate on the cure rates of Helicobacter pylori eradication

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0005871

Enrollment

252

Registered

2021-02-05

Start date

2019-06-03

Completion date

Unknown

Last updated

2021-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : . The standard treatment group was defined as H. pylori eradication using the first-line triple 7-day regimen (esomeprazole 40 mg b.i.d. + amoxicillin 1000 mg b.i.d. + clarithromycin 500 mg b.i

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ? Patients were eligible if aged between 20 and 70 years ? Patients confirmed presenting H. pylori infection within one year and did not treat H. pylori eradication (include H. pylori-induced gastritis regardless of gastric ulcer) ? Patients received comprehensive information regarding the study, with informed consent obtained before the initiation of any study-related processes

Exclusion criteria

Exclusion criteria: ? Patients who used less than two weeks before the screening visit following as i. PPIs and H2-receptor antagonist ii. Antibiotics including clarithromycin, amoxicillin, metronidazole, and tetracycline iii. Bismuth compound, mucosal protects iv. Corticosteroid v. Food product relating to gastric function ? Patients who used drugs metabolized by CYP450 becuase cimetidine strongly suppress and increases concentration of drug in serum i. Warfarin ii. Diazepam iii. Propranolol iv. Erythromycin ? a previous gastric malignancy ? Previous gastric operation ? Comorbidity i. Dialysis ii. Diet with restrictive potassium iii. Uncontrolled nephropathy or hepatic disease ? Alalarming signs (e.g., abnormal weight loss, hematochezia, anemia, or significant bowel habit changes) ? pregnant, planning to pregnancy or breastfeeding ? drug users or alcoholics ? Inappropriate candidate according to researchers' judgement

Design outcomes

Primary

Measure	Time frame
Successful H. pylori eradication was evaluated using 13C-UBT	—

Secondary

Measure	Time frame
Adverse events	—

Countries

Korea, Republic of

Contacts

Public ContactJin Young Yoon

Kyung Hee University Hospital at Gangdong

Outcome results