None listed
Conditions
Interventions
Drug : Intervention group 1 takes Udenafil, 100mg once daily, orally for the first 3 days, and then does not take the drug for 3 days.
Intervention group 2 does not take the drug for the first 3 days,
Sponsors
Jeonbuk National University Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: -Adult males aged 55 to 65 years old -After hearing and understanding the detailed explanation of this study, the subject voluntarily decides to participate in the study and gives written consent -When the MMSE score is taken into account of age, gender, and education level, it is at a normal level of mean-1SD or higher. -Those who are willing to cooperate with this study and complete all phases of clinical trials, and who are practically viable
Exclusion criteria
Exclusion criteria: 1. If you have a history of stroke, myocardial infarction, or CABG surgery within the past 6 months 2. Has a history of cardiac failure, unstable angina, or life-threatening arrhythmia within the last 6 months 3. If you have uncontrolled diabetes 4. If you have proliferative diabetic retinopathy 5. Spinal cord injury, radical prostatectomy and radical pelvic surgery 6. If you have hypotension of less than 90/50mmHg or uncontrolled hypertension of more than 170/100mmHg 7. If there is an abnormality in liver function or kidney function 8. If you have retinitis pigmentosa 9. Severe active peptic ulceration within the past year 10. If you have a blood disorder (sickle cellosis, multiple myeloma, leukemia) or bleeding disorder that may predispose to persistent erection 11. In case the researcher determines that it is unsuitable for participation in the test, such as mental disorder or continuous abuse of drugs 12. When taking Nitrates/Nitric oxide(NO) donor (ex. nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, amyl nitrate/nitrite, Sodium nitroprusside) 13. If you are being treated with cancer chemotherapy 14. If you are taking anticoagulants 15. Taking drugs or foods that affect the metabolism of CYP3A4 in the liver 16. If you are taking Androgens (ex. testosterone) or anti-androgens 17. Use of other PDE-5 inhibitors (Viagra®, Levitra® and Cialis®) or other erectile dysfunction treatments for the treatment of erectile dysfunction within 2 weeks prior to trial 18. History of hypersensitivity to other PDE-5 inhibitors (Viagra®, Levitra® and Cialis®)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reactive brain blood flow obtained by near-infrared spectroscopy | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function test result | — |
Countries
Korea, Republic of
Contacts
Public ContactKo Woon Kim
Jeonbuk National University Hospital
Outcome results
None listed