respiratory depression effect of dexmedetomidine for sedation in total knee replacement

The comparison of respiratory depression between propofol and propofol in combination with dexmedetomidine for deep sedation during total knee replacement under spinal anesthesia: a prospective randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0005749

Enrollment

Registered

2021-01-08

Start date

2021-02-15

Completion date

Unknown

Last updated

2021-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : All patients are randomly assigned to two groups. As a sedative drug, the experimental group received dexmedetomidine in a loading dose of 1mcg/kg for 10 minutes, followed by conti

s assessment of alertness/sedation scale (MOAA/S) is satisfied, and the occurrence of respiratory depression is recorded.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: American society of anesthesiology (ASA) physical status 1, 2, 3 Age: 50-80 yrs Patients for total knee replacement surgery under spinal anesthesia

Exclusion criteria

Exclusion criteria: Severe bradycardia, HR <50 ?/min Severe cardiopulmonary disease, ASA 4?? Severe hepatic or renal disease Body mass index > 35 contraindication to spinal anesthesia Allergy to study medicine, propofol, dexmedetomidine History of severe obstructive sleep apnea or a tendency for airway obstruction Refusal of intraoperative sedation

Design outcomes

Primary

Measure	Time frame
Respiratory compilcation (respiratory depression, airway obstruction)	—

Secondary

Measure	Time frame
postioperative pain	—

Countries

Korea, Republic of

Contacts

Public ContactYoungin Lee

The Catholic University of Korea, Daejeon St. Mary's Hospital

Outcome results