inflammation and medication in femtosecond laser-assisted cataract surgery

Effect of Preoperative Eyedrops on Cytokine Concentrations in Aqueous Humor of Patients Undergoing Femtosecond Laser-Assisted Cataract Surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0005717

Enrollment

120

Registered

2020-12-29

Start date

2020-01-17

Completion date

Unknown

Last updated

2021-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : A total of 120 patients undergoing femtosecond laser-assisted cataract surgery were randomly assigned to four groups of 30 patients each who were administered no eyedrops, fluorometholone 0.1&#

(Flumetholone®) eyedrops, ketorolac tromethamine 0.45&#37

(ACUVAIL®) eyedrops, and both 0.1&#37

fluorometholone and 0.45&#37

ketorolac tromethamine. Eyedrops were instilled 1 hour, 20 minutes, and just before surgery. After femtosecond laser surgery, a corneal incision of about 1 mm was made in the 2 o&#39

clock position, and about 0.1 cc aqueous humor was obtained using a 1 cc syringe and a 26-gauge needle. Cytokine and PGE2 concentrations were quantitatively determined.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients with uncomplicated senile cataract undergoing unilateral femtosecond laser-assited cataract surgery

Exclusion criteria

Exclusion criteria: patients with history of ocular surgery or trauma, corneal opacity, retinopathy, glaucoma, uveitis, amblyopia or complication including intraoperative posterior capsule rupture

Design outcomes

Primary

Measure	Time frame
IL-6 concentration in aqueous humor;IL-8 concentration in aqueous humor;TNF-a concentration in aqueous humor;PGE2 concentration in aqueous humor	—

Secondary

Measure	Time frame
gender;Eye laterality	—

Countries

Korea, Republic of

Contacts

Public ContactHungwon Tchah

Asan Medical Center

Outcome results