None listed
Conditions
Interventions
Drug : Oxalipatin 60 mg/m2 IV (2 h infusion) on Day 1, every 2 weeks
Nal-IRI 50-60 mg/m2 IV (FBE, 90 min infusion) on Day 1, every 2 weeks
S-1 40mg/m2 oral twice daily on Day 1-7, every 2 weeks
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Age 19 years and older - Histologically or cytologically confirmed, measurable pancreatic adenocarcinoma - Treatment naïve locally advanced or metastatic disease - Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 - Adequate bone marrow function as defined by platelets = 100 x 109/L , neutrophils = 1.5 x 109/L and hemoglobin > 9 g/dL; transfusion is allowed, provided interval is = 7 days prior to screening - Adequate renal function, with serum creatinine 30 kg/m2, lean body weight should be used instead - Adequate hepatic function with serum total bilirubin = 2 x ULN (biliary drainage is allowed for biliary obstruction), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) = 2.5 x ULN (= 5 x ULN is acceptable if liver metastases are present) - History of any second malignancy in the last 3 years; patients with prior history of in-situ cancer or basal or squamous cell skin cancer are eligible. Patients with a history of other malignancies are eligible if they have been continuously disease free for at least 3 years. - Female patients must be either surgically sterile or postmenopausal, or if of childbearing potential must have a negative pregnancy test (serum or urine) prior to enrolment and agree to use effective barrier contraception during the period of therapy and for one month after the last dose. - Written, informed consent to the study
Exclusion criteria
Exclusion criteria: - Endocrine or acinar pancreatic carcinoma - Uncontrolled CNS metastases (Note: Patients who require steroids should be on a stable or decreasing dose to be eligible) - Medical or psychiatric conditions that compromise the patient's ability to give informed consent or to complete the protocol or a history of non-compliance - Obstruction of gastrointestinal tract - Active gastrointestinal bleeding - Myocardial infarction within 6 months prior to the study medication, and other clinically significant heart disease (e.g., unstable angina, congestive heart failure or uncontrolled hypertension) - Evidence of severe or uncontrolled systemic disease or any concurrent condition which in the investigator's opinion makes it undesirable for the patient to participate in the study or which would jeopardise compliance with the protocol *Active infection or an unexplained fever > 38.5°C during screening visits or on the first scheduled day of dosing (at the discretion of the investigator, patients with tumor fever may be enrolled), which in the investigator’s opinion might compromise the patient’s participation in the trial or affect the study outcome *Use of strong CYP3A4 inhibitors or inducers, or strong UGT1A1 inhibitors (patients are ineligible if unable to discontinue the use of strong CYP3A4 or UGT1A1 inhibitors at least 1 week or strong CYP3A4 inducers at least 2 weeks prior to receiving first dose of irinotecan liposome injection), - Presence of any contraindications for irinotecan, nal-IRI, S1 and Oxaliplatin - Female patients who are pregnant (positive pregnancy test at screening) or breast-feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dosing limited toxicity | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall response rate;Overall survival;Progression-free survival;Adverse Events | — |
Countries
Korea, Republic of
Contacts
Public ContactChanghoon Yoo
Asan Medical Center
Outcome results
None listed