None listed
Conditions
Interventions
Drug : ° Group A (Celecoxib vs. placebo)
° Group B (Tramadol+acetaminophen vs. placebo)
Random assignment is carried out according to the order of recruitment through a random check table and divi
Zyrofen 1T tid po
Yuyoung rebamipide 1T tid po x 5 days is administered for postoperative 5 days (however, on the day of surgery, 2 times including 1 hour postoperatively, and after 4 days as tid Take it, and take a to
Sponsors
Chungnam National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Healthy adult males and females without systemic diseases aged 19 to 40 years old -Those who have no abnormal findings on blood tests (CBC, aPTT, PT) conducted within the last 3 weeks -When the impaction of both mandibular third molars is confirmed -On panoramic radiographs, more than 1/3 of the crown is covered with the alveolar bone and need to be surgically extracted. (including both gingival incision, tooth separation, bone removal) -A person who fully understands and agrees with the purpose of the research and voluntarily permits participation in the research
Exclusion criteria
Exclusion criteria: - Have a history of allergy on drugs used in this study (Celecoxib, tramadol, acetaminophen, cefaclor, zaltoprofen, rebamipide) -If there is pericoronitis or benign lesions on the impacted mandibular third molars - If you need to take the analgesic drugs continuously until the time of extraction and maintains analgesic effect -Pregnant or lactating person -Smokers and others who are judged to be inappropriate to participate in clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| amount of pain after extraction | — |
Secondary
| Measure | Time frame |
|---|---|
| occurrence of drug side effect;Time taken from the end of extraction to the first pain and the intensity of the pain at that time | — |
Countries
Korea, Republic of
Contacts
Public ContactSoo-Ho Kim
Chungnam National University Hospital
Outcome results
None listed