None listed
Conditions
Interventions
None listed
Sponsors
Gachon University Gil Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Cognitively Normal (CN) • Normal cognition will be defined according to neuropsychological testing, which didn't fall within 1.5 SD, and Clinical Dementia Rating (CDR) was 0 . - Mild cognitive impairment (MCI): • CDR was 0.5 • Subjects were not be clinically diagnosed with dementia according to Diagnostic and Statistical Manual of Mental Disorders, 4th. Edition, Text-revision (DSM-IV-TR) criteria. - Dementia (AD) - Alzheimer's disease (AD): • CDR = 0.5 • subjects were diagnosed with dementia according to DSM-IV-TR. • subjects were diagnosed with probable AD or possible AD according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA) criteria.
Exclusion criteria
Exclusion criteria: - Subjects who do not meet the inclusion criteria. - Subjects who have history of any significant neurological disease other than AD or VD , such as traumatic brain injury, Parkinson's disease, Huntington's disease, motor neuron disease, or multiple sclerosis. - Subjects who have history of brain tumor, normal presure hydrocephalus, encephalitis, or metabolic encephalopathy. - Subjects who have history of a massive stroke in cerebrum, brain strem or cerebellum. - Subjects who have history of psychiatric disorder. - Subjects unable to undergo MRI or PET scanning. - Pregnent or reast feeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative,topographical analysis, and standardized uptake value ratio (SUVR) map generation for 18F-Flutemetamol PET and 18F-DPA-714 PET;Generation of the cortical cortical thickness map through anatomical MRI;Generation of structural connectivity and fiber tractography through Diffusion MRI;Generation of functional connectivity map through Resting-state fMRI | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of cognitive function and brain structure changes between groups during follow-up;Comparison of cognitive function and neuroinflammation between groups during follow-up;Analysis of effect on cognitive impairment and brain atrophy during follow-up | — |
Countries
Korea, Republic of
Contacts
Public ContactYoung Noh
Gachon University Gil Medical Center
Outcome results
None listed