None listed
Conditions
Interventions
None listed
Sponsors
Gachon University Gil Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Cognitively Normal (CN) • Normal cognition will be defined according to neuropsychological testing, which didn't fall within 1.5 SD, and Clinical Dementia Rating (CDR) was 0 . - Mild cognitive impairment (MCI): • CDR was 0.5 • Subjects were not be clinically diagnosed with dementia according to Diagnostic and Statistical Manual of Mental Disorders, 4th. Edition, Text-revision (DSM-IV-TR) criteria. - Dementia (AD and SVaD) - Alzheimer's disease (AD) • CDR = 0.5 • subjects were diagnosed with dementia according to DSM-IV-TR. • subjects were diagnosed with probable AD or possible AD according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA) criteria. - Subcortical vascular dementia (SVaD) • CDR = 0.5 • Subjects were diagnosed with vascular dementia according to DSM-IV-TR. • In FLAIR images, whitematter hyperintensity was more than moderate according to the modified Fazeka’s scale.
Exclusion criteria
Exclusion criteria: - Subjects who do not meet the inclusion criteria. - Subjects who have history of any significant neurological disease other than AD or VD , such as traumatic brain injury, Parkinson's disease, Huntington's disease, motor neuron disease, or multiple sclerosis. - Subjects who have history of brain tumor, normal presure hydrocephalus, encephalitis, or metabolic encephalopathy. - Subjects who have history of a massive stroke in cerebrum, brain strem or cerebellum. - Subjects who have history of psychiatric disorder. - Subjects unable to undergo MRI or PET scanning. - Pregnent or reast feeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analysis of Cognitive Function and Brain Structural Changes Between Groups During Follow-up Assessments(Linear mixed model), and Evaluation of the Imp act on Cognitive Impairment and Brain Atrophy(Cox proportional hazard mode l) | — |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of the Impact on Cognitive Function and Brain Structural Changes Bet ween Groups - Using Structural Equation Model and Relative Importance Meth od | — |
Countries
Korea, Republic of
Contacts
Public ContactYoung Noh
Gachon University Gil Medical Center
Outcome results
None listed