None listed
Conditions
Interventions
Drug : 1. Drug 1) Estrogen: 17ß-estradiol 1 mg (2 pumps)/day,
0.1% percutaneous gel (Estreva gel, Samil Pharm. Co., Seoul, Korea) 2)
Progestogne: micronized progesterone 100 mg(1 capsule)/day, per o
Sponsors
Samsung Medical Center
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Postmenopausal women (duration of amenorrhea: 12 months or longer or serum follicle-stimulating hormone value: 30 mIU/mL or higher) Grade 1 hypertension: according to clinic BP measured at the arm, systolic BP of 140 to 159 mmHg or diastolic BP of 90 to 99 mmHg. Women with uncontrolled hypertension using antihypertensive medication for at least six months Women whose BP was controlled but who wanted to hold their BP medication were included if the BP rebounded only to grade 1 after two weeks of washout.
Exclusion criteria
Exclusion criteria: Symptomatic coronary heart disease or stroke Current or recent (within one year prior to enrollment) smoking Uncontrolled diabetes mellitus (glycated hemoglobin > 8%) Secondary hypertension Hypertension with serious target organ injury suspected Current or recent (within three months before the time of the study entry) MHT use Contraindications for MHT including acutely impaired liver function, breast cancer, and venous thrombosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ambulatory blood pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| Arterial stiffness | — |
Countries
Korea, Republic of
Contacts
Public ContactByung-Koo Yoon
Samsung Medical Center
Outcome results
None listed