The Efficacy of Early Diagnosis and Treatment of Adrenal Insufficiency in Epileptic Seizure Adult Patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0005345

Enrollment

102

Registered

2020-08-24

Start date

2020-08-24

Completion date

Unknown

Last updated

2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug, Procedure/Surgery : The patient with suspicion or diagnosed epileptic seizure will be go through rapid ACTH stimulation test on the next morning. Synacthen (tetracosactrin) 250 mcg (IV bolus) wi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age =18 years and = 85 years 2. Suffered from one or more epileptic seizures (detected clinically and/ or by EEG) 3. Expected ICU stay > 48 hours

Exclusion criteria

Exclusion criteria: 1. Recent ACTH deficiency (pituitary surgery, pituitary stalk trauma) 2. Brain death or imminent death (within 24 hours) 3. Pregnancy or Nephrotic syndrome diagnosed patient 4. DNR (do not resuscitate) orders

Design outcomes

Primary

Measure	Time frame
The incidence of Adrenal Insufficiency (AI) in epileptic seizure patient	—

Secondary

Measure	Time frame
Duration of epileptic seizure in ICU (days): AI (+) vs. AI(-);Number of epileptic seizures captured by EEG (episodes): AI (+) vs. AI(-);Number of epileptic seizures diagnosed on the basis of clinical symptoms alone: AI (+) vs. AI(-);Neurologic outcome using mRS and GOS (7, 14 days post-ictal): AI (+) vs. AI(-)	—

Countries

Korea, Republic of

Contacts

Public ContactMoinay Kim

University of Ulsan

Outcome results