None listed
Conditions
Interventions
Procedure/Surgery : We will enroll the 40 paroxysmal atrial fibrillation patients who refractory to the anti-arrhythmic medications and requiring pulmonary vein isolation, either using radiofrequency
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? Male or female patients between 18 - 80 years old ? Atrial fibrillation documented on electrocardiography ? Atrialrial fibrillation refractory to more than one antiarrhythmic or cannot use the antiarrhythmic for its adverse effect ? Sinus rhythm before procedure ? Agree to the study protocol and provide written informed consent
Exclusion criteria
Exclusion criteria: ? Those with conflict of interest ? cannot understand or accept the study protocol ? Persistent atrial fibrillation before procedure ? Anatomical variations not suitable for either RF or CB ablation ? Common pulmonary vein ostium ? Left atrial anterior – posterior diameter > 55mm ? Pulmonary vein ostial size > 26mm ? Active liver disease or liver dysfunction (ALT or AST > x3 normal range) ? Severe congestive heart failure (NYHA Class III or IV) ? Active malignancy ? Pregnancy or breastfeeding ? Life expectancy < 1 year ? Not suitable for participation by attending physician's discretion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Short term change of heart rate variability during 2-weeks after pulmonary vein isolation | — |
Secondary
| Measure | Time frame |
|---|---|
| Long term change of heart rate variability at 3 and 6 months after pulmonary vein isolation;Recurrence of atrial fibrillation at 3 and 6 months after pulmonary vein isolation | — |
Countries
Korea, Republic of
Contacts
Public ContactGi byoung Nam
Asan Medical Center
Outcome results
None listed