None listed
Conditions
Interventions
Drug : 1st. Screening phase
2nd. Induction and stabilization phase (first 1 – 6 weeks)
- Convert into TBP with 75 – 100% of equivalent dose of the culprit strong opioids and stop all strong opioid ex
Sponsors
Gyeongsang National University Changwon Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. age: 18 years or old 2. those who have willing to participate in the trial 3. cancer patients who have been prescribed opioids of MEDD 80 mg or less and who were physically dependent on offending opioids 4. consistent with DSM-5 diagnostic criteria for opioid withdrawal 5. those in whom there is no evidence of cancer or cancer have not progressed for more than 6 months 6. appropriate bone marrow, renal, and hepatic function
Exclusion criteria
Exclusion criteria: 1. co-morbid dependence on high doses of benzodiazepines or other central nervous system depressants or alcohol 2. hypersensitivity on buprenorphine 3. those who were treated with MAO inhibitors during the last 2 weeks 4. pregnant or potential to become pregnant 5. severe respiratory impairment 6. significant untreated psychiatric comorbidity including depressive disorders, antisocial and borderline personality disorder 7. active or chronic suicidal or homicidal ideation or attempts 8. significant medical complications which are prioritized over participating study 9. patients who have a significant pain (more than NRS 4) or who are unable to manage cancer pain without opioids 10. history of being prescribed buprenorphine for any purpose in the last 8 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of opioid discontinuation [Negative urine drug screening (UDS) after 8 weeks of opioid discontinuation] | — |
Secondary
| Measure | Time frame |
|---|---|
| Success rate of opioid discontinuation (by history taking, counselling);Clinical Opioid Withdrawal Scale (COWS);Numeric rating scale (NRS) for desire to use opioids;Quality of life (QoL);adverse events | — |
Countries
Korea, Republic of
Contacts
Public ContactSE IL KO
Gyeongsang National University Changwon Hospital
Outcome results
None listed