None listed
Conditions
Interventions
None listed
Sponsors
Samsung Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients older than 18 years old who meet both of the following conditions: 1. Diagnosed to have bone metastasis from lung cancer at lower T-spine (below T7), L-spine, sacrum, pelvic bones, or proximal femur 2. Planning to undergo systemic therapy (chemotherapy or target therapy) for metastatic bone lesion
Exclusion criteria
Exclusion criteria: Patients with any of the following criteria are excluded: 1. Prior surgery or radiation treatment to the metastatic bone lesion 2. Metallic instrumentation state at the metastatic bone lesion 3. History of previous systemic therapy for lung cancer 4. Contraindication to MRI contrast material, including renal failure (glomerular filtration rate [GFR] less than 30, within 2 months prior to MRI examination), moderate or severe adverse effect to gadolinium contrast material, or other causes 5. Patients who are unsuitable for MRI, such as claustrophobia or poor cooperation due to severe pain 6. Pregnancy or nursing state
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percent change of tumor T2* relaxivity constant (R2*) after systemic therapy (?R2*%) | — |
Secondary
| Measure | Time frame |
|---|---|
| Percent change of tumor volume, apparent diffusion coefficient (ADC), volume transfer constant (Ktrans), constant rate (Kep), blood plasma volume (Vp), volume fraction of the extravascular extracellular matrix (Ve), proton density fat fraction (PDFF), maximum standardized uptake value (SUVmax) after systemic therapy;Local tumor progression;Local progression-free survival | — |
Countries
Korea, Republic of
Contacts
Public ContactJi Hyun Lee
Samsung Medical Center
Outcome results
None listed