None listed
Conditions
Interventions
None listed
Sponsors
MSD Korea
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? Inclusion criteria: subjects aged 70-75 years who received PPSV23 in previous 5-7 years, Subjects who after hearing and fully understanding the details of this clinical trial, voluntarily decides to participate and agrees in writing to comply, who is determined to be appropriate to participate in this clinical trial through self-disease, physical examination, and researcher's clinical judgment that can be visited and traced to all predetermined schedules of this clinical trial.
Exclusion criteria
Exclusion criteria: Those who have been identified for pneumococcal infection in the past 5 years, those who have been treated with anti-cancer therapy for malignant tumors within the past 30 days, those who have received high doses of systemic steroids within the past 30 days (Prednisolone>0.5 mg/kg/day ), those who have received a blood product within the past 6 months, patients with significant acute or chronic infections within the past 7 days, or those who have had a fever in the previous day, who have a serious chronic or progressive disease, for medical reasons or other reasons, therefore, the investigator is determined to be unsuitable for participation in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GMT and seroconversion rates of IgG antibody titers against 13 pneumococcal serotypes (serotypes 1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F and 23F);GMT and seroconversion rates of opsonophagocytic killing assay (OPA) for 4 pneumococcal serotypes (serotypes 5, 6B, 18C, 19A) | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of adverse reactions in the inoculation site such as pain, tenderness, induration, and redness;systemic adverse reactions such as fever, fatigue, muscle pain, and headache;All unexpected adverse events that occur within 1 month after inoculation in addition to the expected adverse events. | — |
Countries
Korea, Republic of
Contacts
Public ContactHye Seong
Koera University Guro Hospital
Outcome results
None listed