None listed
Conditions
Interventions
Dietary Supplement : The experimental group will take multivitamin and mineral complex containing Agaricus blazei mushroom powder(NK365, NKMAX Korea INC) 4 capsules orally twice a day for 28 days afte
Sponsors
Kyung Hee University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Male or female adult patients aged 19 years old and above 2) Histologically confirmed stage I, II, IIIA NSCLC patients according to TNM classification for lung cancer of the International Association, 8th edition 3) ECOG performance status 0~2 4) Patients without other organ failure and Lung-resectable on the basis of cardiac and pulmonary function tests 5) Adequate kidney and liver function: -Total bilirubin = 1.25 X UNL -AST(SGOT) ? ALT(SGPT) = 3.0 X UNL -Alkaline phosphatase = 2.5 X UNL -Serum creatinine = 1.5 X UNL 6) Patients who are able to comply with the protocol and provide written informed consent for the study voluntarily 7) Patients who agree that other health supplements, multivitamin and mineral complex, agaricus mushroom and related health functional foods are not allowed during the study period
Exclusion criteria
Exclusion criteria: 1) Patients with malignancies other than NSCLC 2) Patients who have undergone surgery within 5 years for other malignancies, with the exception of skin cancer(excluding melanoma) and thyroid cancer 3) Patients who have recieved more than 5mg/day prednisone or equivalent corticosterod within the last month or anticipated requirement for immunosuppressive medications during the study period 4) Patients with prior allogenic stem cell or solid organ transplantation 5) Patients with active acute infection or uncontrolled inflammatory lung disease But patinets with controlled and stable chronic lung disease may be eligible for the study in the opinion of the investigator. 6) Patients with autoimmune diseases or severe systemic diseases that is ineligible for the study participation 7) Patients with histories of mental disorder, alcoholism or drug abuse that could affect the study participation 8) Patients who is inappropriate for the study subject according to the investigator’s judgment 9) Women of childbearing potential 10) Pregnant and lactating women 11) Illiterate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NK cell activity;Immune cell counts (T cell, B cell, etc.);cytokines(IL-6,-10, TGF-beta) | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life;side effect related to the investigational food | — |
Countries
Korea, Republic of
Contacts
Public ContactSeung Hyeun Lee
Kyung Hee University Hospital
Outcome results
None listed