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Effect of magnesium on patients under general anesthesia with trauma surgery

Effect of intraoperative magnesium sulfate administration on postoperative analgesia, recovery and neuroprotective effect in patients under general anesthesia with trauma surgery: a prospective, randomized, double-blinded, controlled study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0005091
Enrollment
80
Registered
2020-06-04
Start date
2019-11-21
Completion date
Unknown
Last updated
2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : The magnesium group starts to infuse magnesium after induction of anesthesia. 30 mg/kg of MgSO4 over a period of 15 minutes. Subsequently, continuous infusion of MgSO4 at a rate of 15 mg/kg/h i

Sponsors

Ajou University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: ASA class 1,2,3 patients undergoing trauma surgery under general anesthesia Patients with informed consent 30 minutes to 5 hours of surgery based on anesthesia time Age: 20 to 79 Patients who are conscious enough to answer the NRS

Exclusion criteria

Exclusion criteria: ASA class 4 or higher Patients who did not give prior consent to the study Surgery with anesthesia time less than 30 minutes or more than 5 hours expected Patients who had already had mechanical ventilation through the tracheal tube before anesthesia induction Kidney dysfunction Neuromuscular diseases (such as myasthenia patients), opioid or analgesic abuse, history of taking previous calcium antagonists Hypermagnesemia patients Atrioventricular block

Design outcomes

Primary

MeasureTime frame
Intraoperative cerebral oximetry

Secondary

MeasureTime frame
Postoperative pain score (Numeric Rating Scale), Postoperative analgesic consumption, Rescue analgesics Frequency / dose

Countries

Korea, Republic of

Contacts

Public ContactHye Min Sohn

Ajou University Hospital

21ambi@hanamail.net+82-31-219-7521

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026