None listed
Conditions
Interventions
None listed
Sponsors
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) patients who were diagnosed as mild cognitive impairment within 3 months from acute cerebral infarct 2) aged 60-80 3) cognitive impairments were newly developed or aggravated after cerebral infarct
Exclusion criteria
Exclusion criteria: 1) patient who was diagnosed as dementia before the cerebral infarct 2) other neurological, psychiatric, or medical disease that cause cognitive impairment 3) patient taking a cholinesterase inhibitor within 3 months from baseline 4) strategic infarct or large territory infarct involving cortical areas 5) modified Rankin Scale (mRS) >3 6) patients with aphasia 7) blindness, deafness, or severe language impairment that might be impossible for study evaluations 8) severe liver disease or kidney disease that needs dialysis 9) malignancy that was not completely resolved 10) schizophremia or bipolar disorders (DSM-IV Axis I psychiatric disease) 11) mental retardation 12) history of encephalitis 13) head trauma history that caused loss of consciousness>1 hour 14) history of traumatic intracranial hemorrhage, brain tumor, or subarachnoid hemorrhage 15) abnormality in thyroid function tests 16) vitamin B12 or folate deficiency 17) neurosyphilis 18) history of metabolic encephalopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination (MMSE) (0~30) | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MOCA) (0~30);Modified Rankin scale (mRS) (0~6);NIHSS (National Institutes of Health Stroke Scale) (0~42);clinical dementia rating (CDR) (0~3);global deterioration scale (GDS) (1~7);white matter hyperintensity grading (minimal, moderate, severe);Scheltens' visual rating scale (hippocampal atrophy grade 0~4) | — |
Countries
Korea, Republic of
Contacts
Public ContactYunJeong Hong
The Catholic University of Korea, Uijeongbu St. Mary’s Hospital
Outcome results
None listed