None listed
Conditions
Interventions
Dietary Supplement : • Test agent (CMU) :A graywhite tablet contained with Weissella cibaria CMU 800 mg
• Control agent (Placebo): A graywhite tablet contained with Isomalt 800 mg same color and same
Sponsors
Kangwon National University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) The person with written consent and acceptable communication capacity 2) The person with 20 years old more 3) The person with 20 natural teeth more 4) The person without tongue health problem (tongue cancer, tongue inflammation, etc.) 5) The person with more tnan 1.5 ng/10ml of VSC (H2S, CH3SH, (CH3)2S)
Exclusion criteria
Exclusion criteria: 1) The person with less than 80%(total intake of 44.8 tablets) compliance of study regimen (total intake of 56 tablets) 2) The person without ability of communicattion in spite of aids of glasses, magnifying glass, hearing-aid 3) The person with mental health problem (schizophrenia, mental retardation, etc.) 4) The person with treatment of systemic health problem causing halitosis (liver disease, kidney disease, Sjögren syndrome, rheumatism, etc.) 5) The person with diagnosis of rhinitis or sinus infection 6) The person with taking antibiotics (correspond to taking during this study, within 2 weeks after screening, or within last 1 month) 7) The person with more than 3 times of normal range of GOT and GPT 8) The person with more than 2 times of normal range of BUN/Creatinine 9) The person with diagnosis of chronic gastritis 10) The person with uncontrollerable high blood pressure (SBP 160mmHg higher or DBP 100mmHg higher) 11) The person with more than 126mg/dL of fasting blood sugar (FBS) or 200mg/dL of random glucose, or current DMpatient with taking insulin or oral hypoglycemic agent 12) The person with continuous intake of oral probiotic related health medicinal products within a week after screening 13) The person with sensitivity or alllergy by probiotic products including dairy product 14) The person with participation to the other human application clinical trial within last 4 weeks 15) The person to be thought Inappropriate in this human application study by research team's judgement 16) The person with taking Warfarin or Aspirin 17) The person with risk of aspiration 18) The person with xerostomia 19) The person with severe perodontal health problem or multiple dental carries, and 5 more dental caries with need of prompt treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VSC via Oral Chroma;Organoleptic test;Self perception of bad breath improvement;Bleeding on probing;Probing depth;Gingival index;Plaque index | — |
Secondary
| Measure | Time frame |
|---|---|
| microorganism count: peridontal bacteria and Weissella cibaria;depression;self-esteem;oral health related quality of life;perceived oral health.;The safety index: Vital signs(Blood pressure, pulse, body temperature), Liver funtion test, Kidey fuction test, Complete blood count, Abnormal reaction survey. | — |
Countries
Korea, Republic of
Contacts
Public ContactDongsuk Lee
Kangwon National University
Outcome results
None listed